In the world of beauty, the range of products available can be overwhelming. There’s everything from SPF and salicylic acid to day and night creams, just to name a few.

New, revolutionary ingredients appear on the beauty scene every so often, but there’s one that’s changed the game and shouldn’t go unmentioned: EGF.

Never heard of it? Well, the scientific community has been researching this area for a long time, yet it’s properties have only recently been harnessed within the cosmetic world to create groundbreaking products.

We’ll be explaining everything you need to know about EGF so you know exactly how it works to benefit your skin.

What is EGF and How Does it Work?


Let’s start with the basics: EGF stands for Epidermal Growth Factor.

EGF is a type of naturally occurring protein molecule found in the skin’s fibroblast cells that contributes to cell growth, development and healing. Its makeup consists of 53 amino acids, the building blocks of proteins. EGFs can be found within a number of different mammals, including the human. It’s believed it’s primary purpose is to help renew the skin after it’s been injured.

The outer layer of the skin is called the epidermis, so as the name suggests, EGF recognises and binds to a specific receptor that lies on the outer layer of the skin. Once this happens, the skin cells’ receptors deliver a message to increase the production of cells in a specific area.

Typically, this all takes place during the inflammation stage after an injury has occurred. EGF is processed and attracts cells to that area to allow the skin to repair itself evenly and quickly; it’s crucial to the healing and regeneration process.

Body Skin Growth EGF Source: Ivan Gabovitch

How Does EGF Work in Skin Products?


In addition to being able to heal injuries to skin, like a scraped knee, EGF can also be harnessed to heal the effects of ageing through the same process.

When EGF is infused into a product and applied to the skin, the same cells are activated and work to thicken the epidermis on that specific area. In aesthetic terms, this means a plumper, more youthful complexion that combats the thinning of skin caused by ageing.

What’s more, EGFs can deliver various messages that translate into different cellular activities. Research has heavily suggested that some of these messages can lead to an increased production in collagen and elastin fibres. This means that EGF products can help to increase and maintain these fibre levels that keep your skin firm and keep sagging and wrinkles at bay.

To date, all other companies that use cellular activators in their skin care products use proteins produced by bacteria (E.coli), hamster cells or yeast. However, BIOEFFECT is the first brand to manufacture EGF from barley instead of animal tissue or bacteria.

This plant-based EGF ensures that our product is entirely void of bacterial endotoxins, human infectious agents and other potential contaminants associated with conventional production hosts. BIOEFFECT’s EGF growth have an unparalleled level of purity and activity.

Barley Plantation EGF Production

Who Discovered EGF?


It was during the 1980s that biochemist Stanley Cohen and Dr Rita Levi-Montalcini were doing experiments and research that would lead to the discovery of Epidermal Growth Factor.

Stanley Cohen has recounted how it was in the Zoology department of Washington University that he first expanded upon Dr. Levi-Montalcini’s observations about her Nerve Growth Factor (NGF) experiments. He noticed that the new-born mice in the experiments had begun to open their eyelids and develop teeth much earlier than usual.

Cohen and Levi-Montalcini decided to research these side effects of the experiment and ended up discovering another growth factor: EGF. Their research and results demonstrated that EGF stimulated the increase of epidermal cells, which didn’t depend on any systemic or hormonal influences.

For the miraculous discovery of this growth EGF, both Cohen and Levi-Montalcini were awarded a Nobel Prize in Medicine in 1986.

Although the research didn’t make a huge impact at the time it was published, they began the research that has helped the scientific community understand how cells interact with each other. Because of their work, our progress and understanding of the roles growth factors and proteins play in cell differentiation has significantly advanced.

Following this research, EGF was then used to treat burn wounds and is now being researched for revolutionary scientific advances like the bioengineering of artificial organs.

Discoverers EGF Nobel Prize

Why Use EGF?


Since EGF is a naturally occurring protein molecule, levels of it are found in all humans and many mammals. All sorts of different growth factors are present from birth until adulthood while our bodies develop their bones, organs, nerves and skin.

However, as the body reaches maturity, the production of these growth factors begins to diminish. EGF levels begin to decrease at the age of 20 after which our skin becomes thinner by 1% each year. After menopause, the skin becomes 30% thinner and the rate at which wounds heal slows down. This is all caused because a decline in EGF means a deterioration in cell turnover and repair.

Both the effects of ageing and decline of EGF levels can be combated by using EGF skin care. When EGF is applied to the skin, in the form of a serum for example, the skin cells’ receptors deliver a message to increase the production of specific cells, collagen and elastin within the skin.

Introducing this level of EGFs back into your system is an effective way to make up for the decline. In turn, your skin will be rejuvenated and the effects of ageing reversed. In fact, Dr Martina Kerscher, a professor of cosmetic Science at University of Hamburg, conducted an independent study on the effects of our EGF Serum.

During the ‘half-a-face’ study, women saw a 60% increase in skin thickness and a 30% increase in collagen density on the side of the face EGF Serum had been applied to.

Woman Skincare EGFs Growth Source: Kylie Aquino

How Should I Use EGF Products?


With all the science covered, all that remains is how best to actually use products that contain EGF. Well, there’s a wide range of EGF products out there that can easily be implemented into your daily skincare routine.

There are day creams, night creams, eye masks that help reduce eye bags and body lotions to help improve your skin’s overall condition.

Here at BIOEFFECT, we suggest that you sparingly apply these products on clean, dry skin. For example, if you’re using a serum, 2-4 drops should suffice for the face and neck area. Smooth in the product and leave to soak in.

If applying other products like makeup after, allow 10 minutes before proceeding. However, for best results, we recommend you use the EGF Serum as part of your evening routine and allow it to absorb overnight.

EGF skin care products are extremely effective when used on their own and eliminate the need for any other moisturisers or anti-aging products. However, they can also improve the impact of other beauty treatments such as peels, microdermabrasion, micro-needling or any type of exfoliation.

By applying an EGF serum after these procedures, your body’s natural EGFs will be drawn to the seemingly ‘injured’ area as well as the serum’s.The result is double the level of EGFs that work to leave your skin smoother and firmer and decrease volume of fine lines and wrinkles.

So, if you’re searching for a skincare ingredient that will reduce the signs of age, rejuvenate the skin and combat traces of skin damage, give EGF a try. We’re certain you won’t be disappointed.